Fractures after Long-Term Alendronate Therapy

An emerging pattern of subtrochanteric stress fractures: a long-term complication of alendronate therapy?

BACKGROUND Subtrochanteric insufficiency fractures in post-menopausal patients have not been commonly reported in the literature. A recent increase in the incidence of such fractures occurring in patients while on alendronate therapy led us to conduct a retrospective review of these patients in our institution. METHODS Seventeen patients, with a mean age of 66 years, sustained low energy subt...

Bilateral Femoral Insufficiency Fractures Likely Related to Long-Term Alendronate Therapy

Osteoporosis-related fractures are a major public health problem and one in two women and one in four men are affected with osteoporosis-related fractures. Alendronate (Fosamax) is one of the first bisphosphonates used to treat osteoporosis effectively. Recently, however, there is a concern regarding long bone insufficiency fractures related to long-term alendronate therapy. We report a case of...

Simultaneous bilateral atypical femoral fractures after alendronate therapy.

Atypical Femoral Fractures after Long-term Bisphosphonates Therapy: Case Report.

UNLABELLED We present a 77-year-old woman with no histor of trauma, or associated with low-energy trauma, admitted to our clinic after three weeks of a left femoral fracture threated in Orthopedic Clinic. The patient was in treatment with bisphosphonates over 10 years for osteoporosis. DISCUSSION AND CONCLUSIONS The causal re lationship between prolonged bisphosphonate use and the occurrence ...

[Atypical subtrochanteric fractures after long-term bisphosphonate therapy].

There have been many reports published in recent years on atypical subtrochanteric fractures after long-term bisphosphonates therapy. In a description of a few series of cases, fractures of typical clinical course and radiological image have been documented. These fractures are estimated as very rare (2.3 per 10,000 patient-years). It is suggested that a subsequent use of steroids or proton pum...